Effects of Intermittent Interleukin‐2 Therapy on Plasma and Tissue Human Immunodeficiency Virus Levels and Quasi‐Species Expression | Zendy

Joseph A. Kovacs | Zendy; Hiromi Imamichi | Zendy; Susan Vogel | Zendy; Julia A. Metcalf | Zendy; Robin Dewar | Zendy; Michael Baseler | Zendy; Randy Stevens | Zendy; Joseph W. Adelsberger | Zendy; Laurie Lambert | Zendy; Richard T. Davey | Zendy; Robert Walker | Zendy; Judith Falloon | Zendy; Michael A. Polis | Zendy; Henry Masur | Zendy; H. Clifford Lane | Zendy

Open Access

Effects of Intermittent Interleukin‐2 Therapy on Plasma and Tissue Human Immunodeficiency Virus Levels and Quasi‐Species Expression

Author(s) -

Joseph A. Kovacs,

Hiromi Imamichi,

Susan Vogel,

Julia A. Metcalf,

Robin Dewar,

Michael Baseler,

Randy Stevens,

Joseph W. Adelsberger,

Laurie Lambert,

Richard T. Davey,

Robert Walker,

Judith Falloon,

Michael A. Polis,

Henry Masur,

H. Clifford Lane

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315821

Subject(s) - tonsil , human immunodeficiency virus (hiv) , virus , immunopathology , immunology , interleukin , cohort , virology , interleukin 2 , medicine , viral disease , biology , cytokine

To characterize the effects of intermittent interleukin (IL)-2 therapy on human immunodeficiency virus (HIV), 11 patients underwent detailed virological evaluation during a year of IL-2 therapy. Six patients showed a >0.5 log increase in plasma HIV during at least 1 IL-2 cycle, with 2 experiencing an increase in >50% of cycles. Three of the remaining 5 patients had a >0.5 log decrease during at least 1 IL-2 cycle, and the remaining patients exhibited <0.5 log changes. No changes in lymphoid (tonsil) levels of HIV were seen during the year. Quasi-species analysis in a separate cohort demonstrated that the virus induced by IL-2 most commonly resembled pre-IL-2 plasma quasi species. Thus, intermittent IL-2 does not result in sustained increases in either plasma or tissue levels of HIV and does not result in sustained expression of a previously silent quasi species.

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