Open AccessRole of Pulmonary Surfactant Protein D in Innate Defense againstCandida albicans
Author(s) -
Bianca A. W. M. van Rozendaal,
Annemiek B. van Spriel,
Jan G. J. van de Winkel,
Henk P. Haagsman
Publication year - 2000
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/315799
Subject(s) - collectin , candida albicans , corpus albicans , microbiology and biotechnology , surfactant protein d , biology , phagocytosis , innate immune system , alveolar macrophage , mannose receptor , macrophage , pulmonary alveolus , immunology , immune system , in vitro , biochemistry
Pulmonary surfactant protein D (SP-D), which is a member of the collectin family, is implicated in pulmonary defense against pathogens. To determine whether SP-D is involved in first-line immunity against Candida albicans, an important respiratory fungus, the interaction of SP-D with C. albicans was studied. SP-D was found to bind C. albicans, resulting in agglutination of the microorganisms. Binding was calcium dependent and was inhibited by competing sugars maltose or mannose. Incubation of C. albicans with SP-D resulted in profound fungal growth inhibition and decreased hyphal outgrowth. Furthermore, it was found that SP-D inhibited phagocytosis of C. albicans by alveolar macrophages. These data suggest that the lung collectin SP-D has an important role in first-line defense against C. albicans in the lung, by agglutinating C. albicans and limiting their growth, without the need for macrophage activation.
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