Longitudinal Dynamics of Epstein‐Barr Virus–Specific Cytotoxic T Lymphocytes during Posttransplant Lymphoproliferative Disorder | Zendy

Kiyotaka Kuzushima | Zendy; Hiroshi Kimura | Zendy; Yo Hoshino | Zendy; Ayami Yoshimi | Zendy; Ikuya Tsuge | Zendy; Keizo Horibe | Zendy; Tsuneo Morishima | Zendy; Tatsuya Tsurumi | Zendy; Seiji Kojima | Zendy

Open Access

Longitudinal Dynamics of Epstein‐Barr Virus–Specific Cytotoxic T Lymphocytes during Posttransplant Lymphoproliferative Disorder

Author(s) -

Kiyotaka Kuzushima,

Hiroshi Kimura,

Yo Hoshino,

Ayami Yoshimi,

Ikuya Tsuge,

Keizo Horibe,

Tsuneo Morishima,

Tatsuya Tsurumi,

Seiji Kojima

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315791

Subject(s) - cytotoxic t cell , virus , epstein–barr virus , virology , lymphoproliferative disorders , immunology , post transplant lymphoproliferative disorder , dynamics (music) , medicine , biology , lymphoma , in vitro , genetics , physics , acoustics

Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD) is a serious complication after allogeneic bone marrow transplantation (BMT). Dynamics of EBV-specific cytotoxic T lymphocytes (CTL), which are important in controlling EBV during the LPD, have not been fully elucidated. A patient with Wiskot-Aldrich's syndrome was diagnosed as suffering from LPD on day 47 after BMT. Fluorescence-activated cell sorter (FACS) analysis for interferon-gamma production revealed that >70% of the patient's CD8(+) T cells were EBV specific. The patient's lymphocytes were directly cytotoxic to donor-derived EBV-positive lymphoblastoid cells, which was blocked by an anti-class I antibody. EBV-specific CD8(+) T cell counts declined in parallel with EBV genome load, and full recovery of LPD was obtained with relaxation of immunosuppressive drugs. The results illustrate longitudinal dynamics of EBV-specific CTL during the posttransplant LPD; they also illustrate the advantages of using FACS analysis for EBV-specific CTL to make decisions about treatment.

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