Incidence and Genetic Diversity of Group C Rotavirus among Adults | Zendy

Mikael Nilsson | Zendy; Bo Svenungsson | Zendy; KjellOlof Hedlund | Zendy; Ingrid Uhnoo | Zendy; Å. Lagergren | Zendy; Tor Akre | Zendy; Lennart Svensson | Zendy

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Incidence and Genetic Diversity of Group C Rotavirus among Adults

Author(s) -

Mikael Nilsson,

Bo Svenungsson,

KjellOlof Hedlund,

Ingrid Uhnoo,

Å. Lagergren,

Tor Akre,

Lennart Svensson

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315772

Subject(s) - rotavirus , diarrhea , feces , group a , incidence (geometry) , biology , virology , reoviridae , prospective cohort study , rotavirus infections , outbreak , genetic diversity , molecular epidemiology , microbiology and biotechnology , medicine , gene , genotype , virus , gastroenterology , genetics , environmental health , population , physics , optics

Fecal samples from a 1-year prospective study were investigated to establish the role of group C rotavirus infections in acute diarrhea in Swedish adults (>15 years old). Rotaviruses were found in samples from 3% of the patients, and, in 35% of these, group C rotavirus was detected. Clinical symptoms of group C rotavirus infection were generally milder than those of group A rotavirus infection. Gene 8 (vp7) from 12 group C isolates, including strains from the prospective study, a military outbreak, and a sporadic case, was sequenced. The gene was found to be extremely conserved, with identities of 99.1%-100% at the amino acid level. This study has systematically investigated the prevalence and genetic diversity of group C rotavirus in adults. The data confirm the extreme sequence conservation within human group C rotavirus strains and suggest that symptomatic group C rotavirus infections occur more frequently in adults than has been previously recognized.

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