Molecular Analysis of Human Immunodeficiency Virus Strains Associated with a Case of Criminal Transmission of the Virus | Zendy

Christopher J. Birch | Zendy; Rhonda McCaw | Zendy; Dieter Bulach | Zendy; Peter Revill | Zendy; J. Tom Carter | Zendy; Jane Tomnay | Zendy; Beth Hatch | Zendy; Tracey Middleton | Zendy; Doris Chibo | Zendy; Michael Catton | Zendy; Jacinta L. Pankhurst | Zendy; Alan Breschkin | Zendy; Stephen Locarnini | Zendy; D. Scott Bowden | Zendy

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Molecular Analysis of Human Immunodeficiency Virus Strains Associated with a Case of Criminal Transmission of the Virus

Author(s) -

Christopher J. Birch,

Rhonda McCaw,

Dieter Bulach,

Peter Revill,

J. Tom Carter,

Jane Tomnay,

Beth Hatch,

Tracey Middleton,

Doris Chibo,

Michael Catton,

Jacinta L. Pankhurst,

Alan Breschkin,

Stephen Locarnini,

D. Scott Bowden

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315751

Subject(s) - contact tracing , virology , phylogenetic tree , biology , virus , transmission (telecommunications) , human immunodeficiency virus (hiv) , group specific antigen , sequence analysis , molecular epidemiology , lentivirus , gene , viral disease , genetics , genotype , medicine , covid-19 , pathology , disease , infectious disease (medical specialty) , electrical engineering , engineering

An investigation was done of the evidence for transmission of human immunodeficiency virus (HIV) from an HIV-positive man to several male and female sex contacts. Phylogenetic analysis of sequences from the gag and env genes showed a close relationship between the predominant virus strains from the source and 2 contacts. However, the likelihood that a female contact was infected by the source could not be determined, despite contact tracing indicating that this may have occurred. One male, shown by contact tracing and molecular evidence to have been infected by the source, subsequently transmitted HIV to his female sex partner. HIV sequence from a plasma sample used as a control in the phylogenetic analysis contained env and gag sequences that were closely related to those from the source. An epidemiologic link between these 2 individuals was subsequently confirmed by contact tracing.

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