Cytolethal Distending Toxin in Avian and Human Isolates ofHelicobacter pullorum | Zendy

Vincent B. Young | Zendy; ChihChing Chien | Zendy; Kimberly A. Knox | Zendy; Nancy S. Taylor | Zendy; David B. Schauer | Zendy; James G. Fox | Zendy

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Cytolethal Distending Toxin in Avian and Human Isolates ofHelicobacter pullorum

Author(s) -

Vincent B. Young,

ChihChing Chien,

Kimberly A. Knox,

Nancy S. Taylor,

David B. Schauer,

James G. Fox

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315705

Subject(s) - cytolethal distending toxin , biology , microbiology and biotechnology , helicobacter , toxin , virulence factor , virulence , human pathogen , campylobacter , polymerase chain reaction , organism , virology , bacteria , helicobacter pylori , microbial toxins , genetics , gene

Helicobacter pullorum has been isolated from the feces and livers of poultry and is associated with human gastroenteritis. Discrimination of this organism from other enterohepatic Helicobacter species and Campylobacter species has proven difficult. H. pullorum from both avian and human clinical sources has DNA sequence homology and cytotoxic activity that represent a new member of the cytolethal distending toxin (CDT) family of bacterial toxins. CDT is a potential virulence factor in H. pullorum that may serve as a distinguishing phenotype and aid in identification of this organism in veterinary and human clinical samples.

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