Stable Enterovirus 5′ Nontranslated Region over a 7‐Year Period in a Patient with Agammaglobulinemia and Chronic Infection | Zendy

James J. Dunn | Zendy; José R. Romero | Zendy; Richard L. Wasserman | Zendy; Harley A. Rotbart | Zendy

Open Access

Stable Enterovirus 5′ Nontranslated Region over a 7‐Year Period in a Patient with Agammaglobulinemia and Chronic Infection

Author(s) -

James J. Dunn,

José R. Romero,

Richard L. Wasserman,

Harley A. Rotbart

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315685

Subject(s) - enterovirus , x linked agammaglobulinemia , period (music) , virology , coxsackievirus , enterovirus infections , biology , medicine , genetics , virus , physics , signal transduction , tyrosine kinase , acoustics , bruton's tyrosine kinase

Cerebrospinal fluid samples obtained 7 years apart from a patient with chronic meningoencephalitis and underlying agammaglobulinemia were examined to determine enteroviral genotypic variability. From each sample, amplicons spanning 496 nucleotides within the 5' nontranslated region were generated directly from the cerebrospinal fluid and analyzed. A consensus sequence derived from 3 clones of each amplicon revealed only 7 nucleotide changes over the 7-year period within the region studied. The observed 5' nontranslated region mutation rate in this patient ( approximately 0.2% per year) was significantly lower than mutation rates reported for the poliovirus genome.

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