The Potential for Vaccine Development against Chlamydial Infection and Disease | Zendy

Robert C. Brunham | Zendy; Dong-ji Zhang | Zendy; Xi Yang | Zendy; G. M. McClarty | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Potential for Vaccine Development against Chlamydial Infection and Disease

Author(s) -

Robert C. Brunham,

Dong-ji Zhang,

Xi Yang,

G. M. McClarty

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315630

Subject(s) - chlamydiae , chlamydia trachomatis , chlamydia , biology , virology , gene , chlamydiaceae , genome , trachoma , chlamydiales , chlamydophila pneumoniae , immunology , microbiology and biotechnology , genetics , medicine , pathology

Chlamydia trachomatis and Chlamydia pneumoniae appear to share a common immunobiology with about 80% of their protein coding genes being orthologs. Progress in DNA vaccine development for C. trachomatis suggests that such a subunit approach may prove useful for C. pneumoniae. The recent finding that it is possible to select for chlamydiae with targeted mutations in key metabolic genes together with the new knowledge of the chlamydia genome also suggests that it may be possible to develop live attenuated strains of chlamydiae for use as vaccine.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research