Comparison of Outer Membrane Protein Genesompandpmpin the Whole Genome Sequences ofChlamydia pneumoniaeIsolates from Japan and the United States | Zendy

Mutsunori Shirai | Zendy; Hideki Hirakawa | Zendy; Kazunobu Ouchi | Zendy; Mitsuaki Tabuchi | Zendy; Fumio Kishi | Zendy; Mitsuaki Kimoto | Zendy; Hiroaki Takeuchi | Zendy; Junko Nishida | Zendy; Kaori Shibata | Zendy; Ryutaro Fujinaga | Zendy; Hiroshi Yoneda | Zendy; Hiroshi Matsushima | Zendy; C. Tanaka | Zendy; Susumu Furukawa | Zendy; Koshiro Miura | Zendy; Atsushi Nakazawa | Zendy; Kazuo Ishii | Zendy; Tadayoshi Shiba | Zendy; Masahira Hattori | Zendy; Satoru Kuhara | Zendy; Teruko Nakazawa | Zendy

Open Access

Comparison of Outer Membrane Protein Genesompandpmpin the Whole Genome Sequences ofChlamydia pneumoniaeIsolates from Japan and the United States

Author(s) -

Mutsunori Shirai,

Hideki Hirakawa,

Kazunobu Ouchi,

Mitsuaki Tabuchi,

Fumio Kishi,

Mitsuaki Kimoto,

Hiroaki Takeuchi,

Junko Nishida,

Kaori Shibata,

Ryutaro Fujinaga,

Hiroshi Yoneda,

Hiroshi Matsushima,

C. Tanaka,

Susumu Furukawa,

Koshiro Miura,

Atsushi Nakazawa,

Kazuo Ishii,

Tadayoshi Shiba,

Masahira Hattori,

Satoru Kuhara,

Teruko Nakazawa

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315616

Subject(s) - biology , gene , whole genome sequencing , genome , genetics , nucleic acid sequence , strain (injury) , chlamydophila pneumoniae , peptide sequence , chlamydia , chlamydiaceae , anatomy

Chlamydia pneumoniae is a widespread pathogen of the respiratory tract that is also associated with atherosclerosis. The whole genome sequence was determined for a Japanese isolate, C. pneumoniae strain J138. The sequence predicted a variety of genes encoding outer membrane proteins (OMPs) including ompA and porB, another 10 predicted omp genes, and 27 pmp genes. All were detected in the whole genome sequence of strain CWL029, a strain isolated and sequenced in the United States. A comparative study of the OMPs of the two strains revealed a nucleotide sequence identity of 89.6%-100% (deduced amino acid sequence identity, 71.1%-100%). The overall genomic organization and location of genes are identical in both strains. Thus, a few unique sequences of the OMPs may be essential for specific attributes that define the differential biology of two C. pneumoniae strains.

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