Inflammation, Infection, or Both in Atherosclerosis: The ROXIS Trial in Perspective | Zendy

Enrique Gurfinkel | Zendy

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Inflammation, Infection, or Both in Atherosclerosis: The ROXIS Trial in Perspective

Author(s) -

Enrique Gurfinkel

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315606

Subject(s) - roxithromycin , medicine , clinical trial , coronary artery disease , antibiotics , inflammation , serology , randomized controlled trial , disease , cardiology , immunology , erythromycin , antibody , microbiology and biotechnology , biology

The role of infection in the instability of atherosclerotic plaques has been questioned because of discrepancies in the results of clinical trials that tested antibiotics in acute coronary syndromes. The results of the Randomized Trial of Roxithromycin in Non-Q-Wave Coronary Syndromes (ROXIS) are summarized and contrasted with two other pilot studies of antibiotic therapy of coronary artery disease. Relevant characteristics of patients enrolled and rationales for these trials are discussed and serologic results are presented.

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