Multiple Drug–ResistantChlamydia trachomatisAssociated with Clinical Treatment Failure | Zendy

Jyoti Somani | Zendy; Vinod Bhullar | Zendy; Kimberly Workowski | Zendy; C E Farshy | Zendy; Carolyn M. Black | Zendy

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Multiple Drug–ResistantChlamydia trachomatisAssociated with Clinical Treatment Failure

Author(s) -

Jyoti Somani,

Vinod Bhullar,

Kimberly Workowski,

C E Farshy,

Carolyn M. Black

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315372

Subject(s) - azithromycin , chlamydia trachomatis , doxycycline , ofloxacin , genotyping , chlamydia , drug resistance , multiple drug resistance , medicine , antibiotics , genotype , immunology , virology , microbiology and biotechnology , biology , ciprofloxacin , biochemistry , gene

In vitro susceptibility testing and genotyping were done on urogenital isolates of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical treatment failure with azithromycin and one of whom was the wife of a patient. All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin, and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due to relapsing infection with the same resistant isolate was documented on the basis of identical genotypes of both organisms. This first report of clinically significant multidrug-resistant C. trachomatis causing relapsing or persistent infection may portend an emerging problem to clinicians and public health officials.

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