Nucleotide Sequences that Distinguish Oka Vaccine from Parental Oka and Other Varicella‐Zoster Virus Isolates | Zendy

Takele Argaw | Zendy; Jeffrey I. Cohen | Zendy; Michael Klutch | Zendy; Kristen Lekstrom | Zendy; Tetsushi Yoshikawa | Zendy; Yoshizo Asano | Zendy; Philip R. Krause | Zendy

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Nucleotide Sequences that Distinguish Oka Vaccine from Parental Oka and Other Varicella‐Zoster Virus Isolates

Author(s) -

Takele Argaw,

Jeffrey I. Cohen,

Michael Klutch,

Kristen Lekstrom,

Tetsushi Yoshikawa,

Yoshizo Asano,

Philip R. Krause

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315335

Subject(s) - orfs , virology , biology , varicella zoster virus , virus , open reading frame , varicella vaccine , chickenpox vaccine , nucleic acid sequence , strain (injury) , coding region , genetics , gene , peptide sequence , antibody , immunization , anatomy

The sequences of approximately 34 kb from the 3' end of the varicella-zoster virus (VZV) Oka vaccine strain and the previously sequenced Dumas strain were compared. Sequence differences were noted in the coding sequences of several VZV open reading frames (ORFs), including ORFs 48, 51, 52, 55, 56, 58, 59, 60, 62, 64, and 68. Tests based on differences in the ORF62 gene and in the ORF64 poly-A region successfully distinguished the Oka vaccine strain from its wild-type parent and from other Japanese and US clinical isolates. These changes remained stable after passage of the virus in humans.

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