Correlates of Immune Protection Induced by Live, Attenuated, Cold‐Adapted, Trivalent, Intranasal Influenza Virus Vaccine | Zendy

Robert B. Belshe | Zendy; William C. Gruber | Zendy; Paul M. Mendelman | Zendy; Harshvardhan B. Mehta | Zendy; Kutubuddin Mahmood | Zendy; Keith S. Reisinger | Zendy; John J. Treanor | Zendy; Ken Zangwill | Zendy; Frederick G. Hayden | Zendy; David I. Bernstein | Zendy; Karen Kotloff | Zendy; James C. King | Zendy; Pedro A. Piedra | Zendy; Stan L. Block | Zendy; Lihan Yan | Zendy; Mark Wolff | Zendy

Open Access

Correlates of Immune Protection Induced by Live, Attenuated, Cold‐Adapted, Trivalent, Intranasal Influenza Virus Vaccine

Author(s) -

Robert B. Belshe,

William C. Gruber,

Paul M. Mendelman,

Harshvardhan B. Mehta,

Kutubuddin Mahmood,

Keith S. Reisinger,

John J. Treanor,

Ken Zangwill,

Frederick G. Hayden,

David I. Bernstein,

Karen Kotloff,

James C. King,

Pedro A. Piedra,

Stan L. Block,

Lihan Yan,

Mark Wolff

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315323

Subject(s) - nasal administration , medicine , live attenuated influenza vaccine , viral shedding , virus , immunology , vaccine efficacy , influenza a virus , virology , antibody , influenza vaccine , attenuated vaccine , nasal spray , placebo , immune system , biology , biochemistry , alternative medicine , pathology , virulence , gene

The authors conducted a 2-year, multicenter, double-blind, placebo-controlled efficacy field trial of live, attenuated, cold-adapted, trivalent influenza vaccine administered by nasal spray to children 15-71 months old. Overall, vaccine was 92% efficacious at preventing culture-confirmed infection by influenza A/H3N2 and influenza B. Because influenza A/H1N1 did not cause disease during the years in which this study was conducted, the authors sought to determine vaccine efficacy and correlates of immune protection against experimental challenge with 107 TCID50 of attenuated H1N1 (vaccine strain) by intranasal spray. Prechallenge assessments included serum hemaglutination-inhibiting (HAI) antibody and nasal wash IgA antibody to H1N1. Vaccine was 83% efficacious (95% confidence interval, 60%-93%) at preventing shedding of H1N1 virus after challenge. Any serum HAI antibody or any nasal wash IgA antibody was correlated with significant protection from H1N1 infection as indicated by vaccine-virus shedding, and high efficacy against H1N1 challenge was demonstrated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research