Rapid Neutrophil Response Controls Fast‐Replicating Intracellular Bacteria but Not Slow‐ReplicatingMycobacterium tuberculosis | Zendy

Peter Seiler | Zendy; Peter Aichele | Zendy; Bärbel Raupach | Zendy; Bernhard Odermatt | Zendy; Ulrich Steinhoff | Zendy; Stefan H. E. Kaufmann | Zendy

Open Access

Rapid Neutrophil Response Controls Fast‐Replicating Intracellular Bacteria but Not Slow‐ReplicatingMycobacterium tuberculosis

Author(s) -

Peter Seiler,

Peter Aichele,

Bärbel Raupach,

Bernhard Odermatt,

Ulrich Steinhoff,

Stefan H. E. Kaufmann

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315278

Subject(s) - intracellular , microbiology and biotechnology , intracellular parasite , bacteria , mycobacterium tuberculosis , biology , virulence , effector , monoclonal antibody , pathogen , virology , tuberculosis , immunology , antibody , medicine , gene , genetics , pathology

Being one of the first cells to invade the site of infection, neutrophils play an important role in the control of various bacterial and viral infections. In the present work, the contribution of neutrophils to the control of infection with different intracellular bacteria was investigated. Mice were treated with the neutrophil-depleting monoclonal antibody RB6-8C5, and the time course of infection in treated and untreated mice was compared by using intracellular bacterial species and strains varying in virulence and replication rate. The results indicate that neutrophils are crucial for the control of fast-replicating intracellular bacteria, whereas early neutrophil effector mechanisms are dispensable for the control of the slow-replicating Mycobacterium tuberculosis.

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