Poly(Sodium 4‐Styrene Sulfonate): An Effective Candidate Topical Antimicrobial for the Prevention of Sexually Transmitted Diseases | Zendy

Betsy C. Herold | Zendy; Nigel Bourne | Zendy; Daniel Marcellino | Zendy; Risa Kirkpatrick | Zendy; Daniel Strauss | Zendy; Lourens J.D. Zaneveld | Zendy; Donald P. Waller | Zendy; Robert A. Anderson | Zendy; Calvin J. Chany | Zendy; Beverly J. Barham | Zendy; Lawrence R. Stanberry | Zendy; M D Cooper | Zendy

Open Access

Poly(Sodium 4‐Styrene Sulfonate): An Effective Candidate Topical Antimicrobial for the Prevention of Sexually Transmitted Diseases

Author(s) -

Betsy C. Herold,

Nigel Bourne,

Daniel Marcellino,

Risa Kirkpatrick,

Daniel Strauss,

Lourens J.D. Zaneveld,

Donald P. Waller,

Robert A. Anderson,

Calvin J. Chany,

Beverly J. Barham,

Lawrence R. Stanberry,

M D Cooper

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315228

Subject(s) - antimicrobial , microbicide , vaginal flora , herpes simplex virus , neisseria gonorrhoeae , microbiology and biotechnology , chlamydia trachomatis , sexually transmitted disease , cytotoxicity , virology , chemistry , medicine , biology , in vitro , virus , human immunodeficiency virus (hiv) , biochemistry , bacterial vaginosis , syphilis

Presently marketed vaginal barrier agents are cytotoxic and damage the vaginal epithelium and natural vaginal flora with frequent use. Novel noncytotoxic agents are needed to protect women from sexually transmitted diseases. One candidate compound is a high-molecular-mass form of soluble poly(sodium 4-styrene sulfonate) (T-PSS). The antimicrobial activity of T-PSS was evaluated in primary culture systems and in a genital herpes murine model. Results obtained indicate that T-PSS is highly effective against herpes simplex viruses, Neisseria gonorrhoeae, and Chlamydia trachomatis in vitro. A 5% T-PSS gel protected 15 of 16 mice from vaginal herpes, compared with 2 of 16 mice treated with a placebo gel. Moreover, T-PSS exhibited little or no cytotoxicity and has an excellent selectivity index. T-PSS is an excellent candidate topical antimicrobial that blocks adherence of herpes simplex virus at low concentrations, inactivates virus at higher concentrations, and exhibits a broad spectrum of antimicrobial activity.

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