Heterogeneous Virulence of EnteroaggregativeEscherichia coliStrains Isolated from Children in Southwest Nigeria | Zendy

Iruka N. Okeke | Zendy; Adebayo Lamikanra | Zendy; John R. Czeczulin | Zendy; Filip Dubovsky | Zendy; James B. Kaper | Zendy; James P. Nataro | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Heterogeneous Virulence of EnteroaggregativeEscherichia coliStrains Isolated from Children in Southwest Nigeria

Author(s) -

Iruka N. Okeke,

Adebayo Lamikanra,

John R. Czeczulin,

Filip Dubovsky,

James B. Kaper,

James P. Nataro

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315204

Subject(s) - enteroaggregative escherichia coli , fimbria , virulence , biology , microbiology and biotechnology , plasmid , diarrhea , escherichia coli , population , gene , enterobacteriaceae , virology , genetics , medicine , environmental health

Enteroaggregative Escherichia coli (EAEC) has been implicated in acute and persistent diarrhea, and most strains harbor a member of a partially-conserved plasmid family (called pAA). We studied EAEC isolated from Nigerian children aged <5 years to elucidate the roles of plasmid and chromosomal EAEC loci. We tested a total of 131 EAEC strains isolated from acute diarrhea case patients and control subjects for hybridization with 8 pAA plasmid-derived and 2 chromosomal gene probes, for several in vitro phenotypes and for resistance to antimicrobial agents. Using by multiple logistic regression, we found genes encoding the AAF/II fimbriae to be strongly associated with diarrhea in this population. EAEC strains appear to be of heterogeneous virulence, and data suggest that AAF/II may be a marker for pathogenic strains.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research