Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis | Zendy

Robin Patel | Zendy; Mark S. Rouse | Zendy; Monica V. Florez | Zendy; Kerryl E. Piper | Zendy; Franklin R. Cockerill | Zendy; Walter R. Wilson | Zendy; James M. Steckelberg | Zendy

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Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis

Author(s) -

Robin Patel,

Mark S. Rouse,

Monica V. Florez,

Kerryl E. Piper,

Franklin R. Cockerill,

Walter R. Wilson,

James M. Steckelberg

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315198

Subject(s) - clindamycin , penicillin , medicine , fasciitis , antibiotics , immunology , microbiology and biotechnology , surgery , biology

Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P<.05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P=.02), penicillin/clindamycin (P=.009), clindamycin/IVIG (P=.04), or all agents combined (P=.02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.

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