Reduced Mobilization of CD34+Stem Cells in Advanced Human Immunodeficiency Virus Type 1 Disease | Zendy

Robert T. Schooley | Zendy; Jeannette Mladenovic | Zendy; Anne Sevin | Zendy; Simon Chiu | Zendy; Steven A. Miles | Zendy; Roger J. Pomerantz | Zendy; Thomas Campbell | Zendy; Dawn Bell | Zendy; Daniel R. Ambruso | Zendy; Robbie Wong | Zendy; Alan Landay | Zendy; Robert W. Coombs | Zendy; Lawrence Fox | Zendy; Malek Kamoun | Zendy; Janice Jacovini | Zendy

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Reduced Mobilization of CD34⁺Stem Cells in Advanced Human Immunodeficiency Virus Type 1 Disease

Author(s) -

Robert T. Schooley,

Jeannette Mladenovic,

Anne Sevin,

Simon Chiu,

Steven A. Miles,

Roger J. Pomerantz,

Thomas Campbell,

Dawn Bell,

Daniel R. Ambruso,

Robbie Wong,

Alan Landay,

Robert W. Coombs,

Lawrence Fox,

Malek Kamoun,

Janice Jacovini

Publication year - 2000

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315168

Subject(s) - cd34 , filgrastim , leukapheresis , granulocyte colony stimulating factor , immunology , stem cell , progenitor cell , myeloid , virology , biology , medicine , chemotherapy , genetics

Granulocyte colony-stimulating factor (r-met Hu G-CSF; filgrastim; 10 microgram/kg/day for 7 days) was used to mobilize CD34+stem cells into the peripheral blood of human immunodeficiency virus type 1 (HIV-1)-infected individuals and a group of HIV-1-uninfected donors as a measure of immunologic reserve in HIV-1-infected people. G-CSF mobilized CD34+ cells of HIV-1-infected individuals with cell counts >500 CD4+ cells/mm3, as well as in HIV-1-uninfected donors. In contrast, CD34 cell mobilization was significantly blunted in HIV-1-infected individuals with cell counts <500 CD4+ cells/mm3 (<200 cell days vs. >650 cell days, P<.0005, compared with the >500 CD4+ cell cohort). At least 1.75x10(7) CD34 cells were harvested by leukapheresis from patients in each study cohort. CD34+ cell viability and the ability to differentiate precursor cells into myeloid and erythroid progenitor cells were not affected by HIV-1 infection.

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