Chloroquine Resistance inPlasmodium falciparumand Polymorphism of theCG2Gene | Zendy

Léonardo K. Basco | Zendy; Pascal Ringwald | Zendy

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Chloroquine Resistance inPlasmodium falciparumand Polymorphism of theCG2Gene

Author(s) -

Léonardo K. Basco,

Pascal Ringwald

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315150

Subject(s) - biology , genotype , plasmodium falciparum , chloroquine , genetics , allele , gene , drug resistance , polymorphism (computer science) , virology , microbiology and biotechnology , malaria , immunology

A distinct genotype (designated Dd2-type profile) consisting of 12 point mutations and 3 repetitive regions of the CG2 gene, a candidate gene for chloroquine resistance, has been associated with in vitro resistance in laboratory-adapted strains of Plasmodium falciparum. The DNA sequence of clinical isolates, characterized by in vitro and in vivo tests, was analyzed to evaluate whether the genotype corresponds to the phenotype in naturally occurring parasites. Eight of 11 chloroquine-resistant isolates had the Dd2 genotype. One resistant isolate (by in vitro assay) with a sensitive CG2 genotype was sensitive in vivo. Two resistant isolates and 6 sensitive isolates were multiple infections with mixed alleles. No typical CG2 genotype was found corresponding to the chloroquine-sensitive isolates. These results suggest a strong association between the drug-resistant and CG2 genotypes and support the hypothesis that the CG2 gene may be implicated in chloroquine resistance.

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