Antibody Response in Individuals Infected with Avian Influenza A (H5N1) Viruses and Detection of Anti‐H5 Antibody among Household and Social Contacts | Zendy

Jacqueline M. Katz | Zendy; Wilina Lim | Zendy; Carolyn B. Bridges | Zendy; Thomas Rowe | Zendy; Jean HuPrimmer | Zendy; Xiuhua Lu | Zendy; Robert A. Abernathy | Zendy; Matthew Clarke | Zendy; Laura A. Conn | Zendy; Heston Kwong | Zendy; Miranda Lee | Zendy; Gareth Au | Zendy; Y.Y. Ho | Zendy; Kwok Hang Mak | Zendy; Nancy J. Cox | Zendy; Keiji Fukuda | Zendy

Open Access

Antibody Response in Individuals Infected with Avian Influenza A (H5N1) Viruses and Detection of Anti‐H5 Antibody among Household and Social Contacts

Author(s) -

Jacqueline M. Katz,

Wilina Lim,

Carolyn B. Bridges,

Thomas Rowe,

Jean HuPrimmer,

Xiuhua Lu,

Robert A. Abernathy,

Matthew Clarke,

Laura A. Conn,

Heston Kwong,

Miranda Lee,

Gareth Au,

Y.Y. Ho,

Kwok Hang Mak,

Nancy J. Cox,

Keiji Fukuda

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315137

Subject(s) - influenza a virus subtype h5n1 , serology , virology , antibody , transmission (telecommunications) , outbreak , virus , biology , influenza a virus , immunology , antibody response , medicine , electrical engineering , engineering

The first documented outbreak of human respiratory disease caused by avian influenza A (H5N1) viruses occurred in Hong Kong in 1997. The kinetics of the antibody response to the avian virus in H5N1-infected persons was similar to that of a primary response to human influenza A viruses; serum neutralizing antibody was detected, in general, >/=14 days after symptom onset. Cohort studies were conducted to assess the risk of human-to-human transmission of the virus. By use of a combination of serologic assays, 6 of 51 household contacts, 1 of 26 tour group members, and none of 47 coworkers exposed to H5N1-infected persons were positive for H5 antibody. One H5 antibody-positive household contact, with no history of poultry exposure, provided evidence that human-to-human transmission of the avian virus may have occurred through close physical contact with H5N1-infected patients. In contrast, social exposure to case patients was not associated with H5N1 infection.

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