Chlamydia pneumoniaeDNA Detection in Peripheral Blood Mononuclear Cells Is Predictive of Vascular Infection | Zendy

Francesco Blasi | Zendy; Jens Boman | Zendy; Gloria Esposito | Zendy; Germano Melissano | Zendy; Roberto Chiesa | Zendy; Roberto Cosentini | Zendy; Paolo Tarsia | Zendy; Yamume Tshomba | Zendy; Matteo Betti | Zendy; MarieChristine Alessi | Zendy; Nicoletta Morelli | Zendy; L. Allegra | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Chlamydia pneumoniaeDNA Detection in Peripheral Blood Mononuclear Cells Is Predictive of Vascular Infection

Author(s) -

Francesco Blasi,

Jens Boman,

Gloria Esposito,

Germano Melissano,

Roberto Chiesa,

Roberto Cosentini,

Paolo Tarsia,

Yamume Tshomba,

Matteo Betti,

MarieChristine Alessi,

Nicoletta Morelli,

L. Allegra

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315126

Subject(s) - chlamydophila pneumoniae , chlamydia , peripheral blood mononuclear cell , chlamydiaceae , mycoplasma pneumoniae , abdominal aortic aneurysm , pathology , medicine , serology , polymerase chain reaction , immunology , biology , aneurysm , antibody , pneumonia , gene , radiology , biochemistry , in vitro

Abdominal aortic aneurysm tissue and peripheral blood mononuclear cells (PBMC) of 41 consecutive subjects undergoing abdominal aortic aneurysm surgery were analyzed by polymerase chain reaction (PCR) for the presence of Chlamydia pneumoniae, Mycoplasma pneumoniae, and Helicobacter pylori DNA. Twenty patients (49%) were positive for C. pneumoniae DNA-16 (39%) in both PBMC and aneurysm tissue, 3 (7.3%) in PBMC only, and 1 (2.4%) in the artery specimen only. Previous exposure to C. pneumoniae was confirmed in 19 (95%) of the 20 PCR positive subjects by C. pneumoniae-specific serology, using the microimmunofluorescence test. None was positive for H. pylori or M. pneumoniae DNA, either in the PBMC or in the artery specimens. In conclusion, carriage of C. pneumoniae DNA is common both in PBMC and in abdominal aortic tissue from patients undergoing abdominal aneurysm surgery. Blood PCR may be a useful tool for identifying subjects carrying C. pneumoniae in the vascular wall.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research