Open AccessInterference of Antibody Production to Hepatitis B Surface Antigen in a Combination Hepatitis A/Hepatitis B Vaccine
Author(s) -
Sharon E. Frey,
Ron Dagan,
Yaffa Ashur,
Xiao Q. Chen,
José María Miralles Ibarra,
Herwig Kollaritsch,
Mark H. Mazur,
Gregory A. Poland,
Keith S. Reisinger,
Emmanuel B. Walter,
Pierre Van Damme,
Jean Henrik Braconier,
Ingrid Uhnoo,
Martin A. Wahl,
Mark M. Blatter,
Dennis A. Clements,
David Greenberg,
Robert M. Jacobson,
S. Ragnar Norrby,
Mina Rowe,
Daniel Shouval,
Sue S. Simmons,
Jan van Hattum,
Solveig Wennerholm,
Jacqueline Gress,
Ivan S. F. Chan,
Barbara J. Kuter
Publication year - 1999
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/315119
Subject(s) - medicine , hepatitis a vaccine , immunogenicity , hepatitis b vaccine , hepatitis b , hepatitis , virology , hepatitis a , tolerability , immunology , antibody , hepatitis b virus , hbsag , adverse effect , virus
A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.