Transmission of a Multidrug‐ResistantMycobacterium tuberculosisStrain Resembling “Strain W” among Noninstitutionalized, Human Immunodeficiency Virus–Seronegative Patients | Zendy

Annelies Van Rie | Zendy; Robin M. Warren | Zendy; Nulda Beyers | Zendy; Robert P. Gie | Zendy; Collette Natasha Classen | Zendy; Madalene Richardson | Zendy; Samantha L. Sampson | Zendy; T. C. Victor | Zendy; Paul D. van Helden | Zendy

Open Access

Transmission of a Multidrug‐ResistantMycobacterium tuberculosisStrain Resembling “Strain W” among Noninstitutionalized, Human Immunodeficiency Virus–Seronegative Patients

Author(s) -

Annelies Van Rie,

Robin M. Warren,

Nulda Beyers,

Robert P. Gie,

Collette Natasha Classen,

Madalene Richardson,

Samantha L. Sampson,

T. C. Victor,

Paul D. van Helden

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/315054

Subject(s) - virology , ethambutol , restriction fragment length polymorphism , mycobacterium tuberculosis , tuberculosis , outbreak , biology , genotype , transmission (telecommunications) , multiple drug resistance , virus , isoniazid , drug resistance , medicine , microbiology and biotechnology , genetics , gene , pathology , electrical engineering , engineering

Since 1990, several outbreaks of multidrug-resistant tuberculosis (MDR-TB) have been described among institutionalized patients infected with human immunodeficiency virus (HIV). We describe a community MDR-TB outbreak among HIV-seronegative patients in Cape Town, South Africa. Isolates were characterized by restriction fragment length polymorphism (RFLP) analysis and dot-blot hybridization analysis of mutations conferring resistance for isoniazid, rifampin, streptomycin, and ethambutol. All isolates were identical on RFLP analysis. In 2 patients, RFLP analysis showed exogenous reinfection during or after treatment for drug-susceptible TB. Mutation analysis confirmed the genotypic identity of the isolates. The infecting strain was genotypically related to strain W, which is responsible for the majority of MDR-TB outbreaks in New York City. Transmission of MDR-TB is thus not limited to HIV-seropositive patients in an institutional setting but occurs within a community.

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