Open AccessCase‐Control Study of Risk Factors for Avian Influenza A (H5N1) Disease, Hong Kong, 1997
Author(s) -
Anthony W. Mounts,
Heston Kwong,
Héctor S. Izurieta,
Yukyin Ho,
T. Au,
Miranda Lee,
Carolyn B. Bridges,
Seymour W. Williams,
Kwok Hang Mak,
Jacqueline M. Katz,
W. Thompson,
Nancy J. Cox,
Keiji Fukuda
Publication year - 1999
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/314903
Subject(s) - influenza a virus subtype h5n1 , disease , odds ratio , medicine , case control study , respiratory disease , virus , environmental health , immunology , lung
In May 1997, a 3-year-old boy in Hong Kong died of a respiratory illness related to influenza A (H5N1) virus infection, the first known human case of disease from this virus. An additional 17 cases followed in November and December. A case-control study of 15 of these patients hospitalized for influenza A (H5N1) disease was conducted using controls matched by age, sex, and neighborhood to determine risk factors for disease. Exposure to live poultry (by visiting either a retail poultry stall or a market selling live poultry) in the week before illness began was significantly associated with H5N1 disease (64% of cases vs. 29% of controls, odds ratio, 4.5, P=.045). By contrast, travel, eating or preparing poultry products, recent exposure to persons with respiratory illness, including persons with known influenza A (H5N1) infection, were not associated with H5N1 disease.
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