A Randomized Clinical Trial of Acellular Pertussis Vaccines in Healthy Adults: Dose‐Response Comparisons of 5 Vaccines and Implications for Booster Immunization | Zendy

Wendy A. Keitel | Zendy; Larry R. Muenz | Zendy; Michael D. Decker | Zendy; Janet A. Englund | Zendy; ChrisAnna M. Mink | Zendy; Dean A. Blumberg | Zendy; Kathryn M. Edwards | Zendy

Open Access

A Randomized Clinical Trial of Acellular Pertussis Vaccines in Healthy Adults: Dose‐Response Comparisons of 5 Vaccines and Implications for Booster Immunization

Author(s) -

Wendy A. Keitel,

Larry R. Muenz,

Michael D. Decker,

Janet A. Englund,

ChrisAnna M. Mink,

Dean A. Blumberg,

Kathryn M. Edwards

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/314869

Subject(s) - immunogenicity , immunization , medicine , booster dose , titer , placebo , antigen , antibody , immunology , pathology , alternative medicine

The safety and immunogenicity of 5 acellular pertussis vaccines (ACVs) were compared in a multicenter, randomized, double-blind trial. A total of 481 healthy adults were given a single intramuscular booster dose of ACV or placebo. Three different dose levels were tested for 4 ACVs: full strength (the dose level proposed for infant immunization), one-third strength, and one-tenth strength. For 1 multicomponent vaccine, only the pertussis toxoid dose level varied. Minor injection site reactions were common and similar in frequency among vaccinated groups. Late-onset injection site reactions were seen in all ACV groups. Dose-related increases in mean antibody titers against vaccine antigens were seen after immunization with all ACVs. Antibody responses against antigens not known to be present in the vaccines were detected after immunization with 4/5 ACVs. Antibody levels fell significantly during the year after immunization. These data support evaluation of ACVs for broader use among adolescents and adults.

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