Human Immunodeficiency Virus Load in Breast Milk, Mastitis, and Mother‐to‐Child Transmission of Human Immunodeficiency Virus Type 1 | Zendy

Richard D. Semba | Zendy; Johnstone Kumwenda | Zendy; Donald R. Hoover | Zendy; Taha E. Taha | Zendy; Thomas C. Quinn | Zendy; L. A. R. Mtimavalye | Zendy; Robert J. Biggar | Zendy; Robin Broadhead | Zendy; Paolo Miotti | Zendy; Lori J. Sokoll | Zendy; Len van der Hoeven | Zendy; John D. Chiphangwi | Zendy

Open Access

Human Immunodeficiency Virus Load in Breast Milk, Mastitis, and Mother‐to‐Child Transmission of Human Immunodeficiency Virus Type 1

Author(s) -

Richard D. Semba,

Johnstone Kumwenda,

Donald R. Hoover,

Taha E. Taha,

Thomas C. Quinn,

L. A. R. Mtimavalye,

Robert J. Biggar,

Robin Broadhead,

Paolo Miotti,

Lori J. Sokoll,

Len van der Hoeven,

John D. Chiphangwi

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/314854

Subject(s) - mastitis , breast milk , breast feeding , medicine , viral load , transmission (telecommunications) , lentivirus , immunology , viral disease , human immunodeficiency virus (hiv) , virology , biology , pediatrics , pathology , electrical engineering , engineering , biochemistry

Human immunodeficiency virus (HIV) type 1 load in breast milk and mastitis were examined as risk factors for vertical transmission of HIV-1. Six weeks after delivery, HIV-1 load and sodium (an indicator of mastitis) were measured in breast milk from 334 HIV-1-infected women in Malawi. Median breast milk HIV-1 load was 700 copies/mL among women with HIV-1-infected infants versus undetectable (<200 copies/mL) among those with uninfected infants, respectively (P<. 0001). Elevated breast milk sodium levels consistent with mastitis occurred in 16.4% of HIV-1-infected women and were associated with increased vertical transmission of HIV-1 (P<.0001). Median breast milk HIV-1 load was 920 copies/mL among women with versus undetectable among those without elevated breast milk sodium levels, respectively (P<.0001). Mastitis and breast milk HIV-1 load may increase the risk of vertical transmission of HIV-1 through breast-feeding.

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