Severity of Tuberculosis in Mice is Linked to Distal Chromosome 3 and Proximal Chromosome 9 | Zendy

Catharina Lavebratt | Zendy; Alexander Apt | Zendy; B. V. Nikonenko | Zendy; Martin Schalling | Zendy; Erwin Schurr | Zendy

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Severity of Tuberculosis in Mice is Linked to Distal Chromosome 3 and Proximal Chromosome 9

Author(s) -

Catharina Lavebratt,

Alexander Apt,

B. V. Nikonenko,

Martin Schalling,

Erwin Schurr

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/314843

Subject(s) - quantitative trait locus , biology , tuberculosis , mycobacterium tuberculosis , chromosome , genetics , genome , genetic linkage , inbred strain , gene , medicine , pathology

Genetic factors play a role in host response to infection with Mycobacterium tuberculosis, the number one infectious killer worldwide. Mice of the inbred strains I/St and A/Sn show significant differences in disease severity after intravenous injection of a lethal dose of the virulent human isolate M. tuberculosis H37Rv. Following challenge with H37Rv, only I/St mice have rapid body weight loss and short survival times. A genome wide analysis for linkage with body weight after M. tuberculosis H37Rv infection was done in (A/SnxI/St)F1xI/St mice. Among females, quantitative trait loci (QTLs) on chromosomes 9 and 3 were significantly linked to postinfection body weight (logarithm of the odds ratio [LOD] scores of 6.68 and 3.92, respectively). Suggestive linkages were found for QTLs on chromosomes 8 and 17 (LOD scores of 3.01 and 2.95, respectively). For males, QTLs on chromosomes 5 and 10 showed suggestive linkages (LOD scores of 3.03 and 2.31, respectively). These linkages can be used to identify candidate regions for tuberculosis susceptibility loci in the human genome.

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