Fas Receptor Up‐Regulation and Membrane Localization Concurrent with Apoptosis in Idiopathic Esophageal Ulceration: Toward a Better Understanding of Esophageal Injury in AIDS | Zendy

JeanMarie Houghton | Zendy; Reju Korah | Zendy; Kyung Hee Kim | Zendy

Open Access

Fas Receptor Up‐Regulation and Membrane Localization Concurrent with Apoptosis in Idiopathic Esophageal Ulceration: Toward a Better Understanding of Esophageal Injury in AIDS

Author(s) -

JeanMarie Houghton,

Reju Korah,

Kyung Hee Kim

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/314832

Subject(s) - fas ligand , apoptosis , fas receptor , receptor , esophageal ulcer , immunology , cytokine , concomitant , mucous membrane , esophageal disease , signal transduction , basal (medicine) , cancer research , biology , pathology , medicine , endocrinology , esophagus , programmed cell death , microbiology and biotechnology , diabetes mellitus , biochemistry

Activation of the Fas-mediated apoptotic pathway in the etiology of idiopathic esophageal ulcerations (IEUs) was investigated. Constitutive expression of Fas ligand (Fas L) was found in the basal layer of the normal esophageal mucosa and in IEUs and cytomegalovirus ulcerations. In addition to an altered cytokine environment, there was significant up-regulation of Fas antigen mRNA and membrane localization of the receptor in IEU specimens. Concomitant increase in the basic components of Fas machinery, together with elevated mucosal apoptosis, strongly suggests the potential role of the Fas signaling pathway in the onset of tissue destruction associated with IEUs.

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