Open AccessPneumococcal Conjugate Vaccine Primes for Polysaccharide‐Inducible IgG2 Antibody Response in Children with Recurrent Otitis Media Acuta
Author(s) -
Mijke A. Breukels,
Ger T. Rijkers,
Marleen M. VoorhorstOgink,
B.J.M. Zegers,
Lieke A. M. Sanders
Publication year - 1999
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/314705
Subject(s) - otitis , immunology , microbiology and biotechnology , pneumococcal conjugate vaccine , antibody , conjugate , medicine , conjugate vaccine , antibody response , acute otitis media , streptococcus pneumoniae , virology , biology , immunization , mathematics , antibiotics , mathematical analysis , surgery
Children with frequent recurrent episodes of otitis media may have a deficient IgG2 antibody response to polysaccharide antigens. Five otitis-prone children were vaccinated with heptavalent pneumococcal conjugate vaccine. While all had an IgG1 antibody response to all pneumococcal serotypes included in the conjugate vaccine, the IgG2 response, especially to serotypes 6B, 9V, 19F, and 23F, was poor. However, vaccination with a 23-valent polysaccharide vaccine 6 months after conjugate vaccination induced an 11.5- to 163-fold increase in IgG2 anti-polysaccharide antibody titers. Thus, an IgG2 polysaccharide antibody deficiency can be overcome by priming with a pneumococcal conjugate vaccine followed by a booster with a polyvalent polysaccharide vaccine.
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