Molecular Analysis of the Genetic Variation among Penicillin‐Susceptible and Penicillin‐ResistantStreptococcus pneumoniaeSerotypes in Canada | Zendy

Marie Louie | Zendy; Lisa Louie | Zendy; Giuseppe Papia | Zendy; James Talbot | Zendy; Marguerite Lovgren | Zendy; A. E. Simor | Zendy

Open Access

Molecular Analysis of the Genetic Variation among Penicillin‐Susceptible and Penicillin‐ResistantStreptococcus pneumoniaeSerotypes in Canada

Author(s) -

Marie Louie,

Lisa Louie,

Giuseppe Papia,

James Talbot,

Marguerite Lovgren,

A. E. Simor

Publication year - 1999

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/314664

Subject(s) - serotype , penicillin , streptococcus pneumoniae , biology , molecular epidemiology , microbiology and biotechnology , antibiotics , genetics , gene , genotype

Few studies have examined the genetic relatedness within and between serotypes of Streptococcus pneumoniae. Penicillin-susceptible S. pneumoniae (PSSP) isolates (n=170) and penicillin-resistant S. pneumoniae (PRSP) isolates (n=48) belonging to 13 different serotypes from across Canada were studied to further understand the molecular epidemiology of S. pneumoniae. PRSP of serotypes 6B, 14, and 19F appeared to be novel clones, differentiated by pulsed-field gel electrophoresis from the recognized international penicillin-resistant clones belonging to these serotypes. In addition, not all PRSP strains shared similar genetic backgrounds with PSSP strains of the same serotype, suggesting that in Canada, certain PRSP strains have emerged from new unique lineages of PRSP. Although there was significant heterogeneity among S. pneumoniae of different serotypes, certain serotypes (3, 7F, and 22F) appeared to be more clonally related despite having originated from different geographic regions.

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