The Bcg Host-Resistance Gene | Zendy

Natalie Buu | Zendy; Fabio Sánchez | Zendy; Erwin Schurr | Zendy

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The Bcg Host-Resistance Gene

Author(s) -

Natalie Buu,

Fabio Sánchez,

Erwin Schurr

Publication year - 2000

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/314067

Subject(s) - gene , tuberculosis , allele , macrophage , mycobacterium leprae , microbiology and biotechnology , biology , mycobacterium tuberculosis , virology , genetics , immunology , medicine , leprosy , pathology , in vitro

In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Bcg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with human responses to mycobacteria, including susceptibility to tuberculosis and leprosy, as well as BCG immunotherapy in bladder cancer.

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