Resistant Herpes Simplex Virus Type 1 Infection: An Emerging Concern after Allogeneic Stem Cell Transplantation | Zendy

Yolande Chen | Zendy; Catherine Scieux | Zendy; Valérie Garrait | Zendy; Gèrard Socié | Zendy; Vanderson Rocha | Zendy; JeanMichel Molina | Zendy; D Thouvenot | Zendy; Florence Morfin | Zendy; Laurent Hocqueloux | Zendy; Laurent Garderet | Zendy; Hélène Esperou | Zendy; F Selimi | Zendy; Agnès Devergie | Zendy; Ghislaine Leleu | Zendy; Michèle Aymard | Zendy; Frédéric Morinet | Zendy; Éliane Gluckman | Zendy; Patricia Ribaud | Zendy

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Resistant Herpes Simplex Virus Type 1 Infection: An Emerging Concern after Allogeneic Stem Cell Transplantation

Author(s) -

Yolande Chen,

Catherine Scieux,

Valérie Garrait,

Gèrard Socié,

Vanderson Rocha,

JeanMichel Molina,

D Thouvenot,

Florence Morfin,

Laurent Hocqueloux,

Laurent Garderet,

Hélène Esperou,

F Selimi,

Agnès Devergie,

Ghislaine Leleu,

Michèle Aymard,

Frédéric Morinet,

Éliane Gluckman,

Patricia Ribaud

Publication year - 2000

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/314052

Subject(s) - foscarnet , cidofovir , medicine , transplantation , herpes simplex virus , virology , stem cell , immunology , viral disease , virus , herpesviridae , biology , genetics

Fourteen cases of severe acyclovir-resistant herpes simplex virus type 1 (HSV-1) infection, 7 of which showed resistance to foscarnet, were diagnosed among 196 allogeneic stem cell transplant recipients within a 29-month period. Recipients of unrelated stem cell transplants were at higher risk. All patients received foscarnet; 8 subsequently received cidofovir. Strains were initially foscarnet-resistant in 3 patients and secondarily so in 4 patients. In vitro resistance to acyclovir or foscarnet was associated with clinical failure of these drugs; however, in vitro susceptibility to foscarnet was associated with complete response in only 5 of 7 patients. No strain from any of the 7 patients was resistant in vitro to cidofovir; however, only 3 of 7 patients achieved complete response. Therefore, acyclovir- and/or foscarnet-resistant HSV-1 infections after allogeneic stem cell transplantation have become a concern; current strategies need to be reassessed and new strategies must be evaluated in this setting.

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