Open AccessTreatment of Latent Tuberculosis Infection in Patients Aged ≥35 Years
Author(s) -
Shelley A. Gilroy,
Mary A.M. Rogers,
Donald C. Blair
Publication year - 2000
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/314037
Subject(s) - medicine , latent tuberculosis , tuberculosis , mycobacterium tuberculosis , pathology
Treating patients aged > or =35 years for tuberculosis infection has been controversial because of the hepatotoxic effects of isoniazid. A 2-year retrospective cohort study of outpatient medical records determined the completion rate in this age group and identified risk factors associated with isoniazid-associated hepatotoxicity. Isoniazid preventative therapy was well tolerated. However, toxicity occurred in women receiving concomitant medications and men who used alcohol.
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