Simple, Practical Ways to Assess the Protective Efficacy of a New Tuberculosis Vaccine | Zendy

George W. Comstock | Zendy

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Simple, Practical Ways to Assess the Protective Efficacy of a New Tuberculosis Vaccine

Author(s) -

George W. Comstock

Publication year - 2000

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/313870

Subject(s) - medicine , tuberculin , tuberculosis , bcg vaccine , vaccination , immunology , clinical trial , tuberculosis vaccines , randomized controlled trial , mycobacterium tuberculosis , virology , pathology

There is strong evidence that tuberculin sensitivity cannot be used to evaluate the efficacy of different strains of bacille Calmette-Guérin (BCG). For identifying efficacious strains of BCG and evaluating candidates for new vaccines, the best method is a randomized trial. Simple trials in which newborns would be vaccinated with new and old vaccines in alternate years could demonstrate which vaccine was the better.

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