Kallikrein-Kinin System Activation in Streptococcal Toxic Shock Syndrome | Zendy

Shiranee Sriskandan | Zendy; Jon Cohen | Zendy

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Kallikrein-Kinin System Activation in Streptococcal Toxic Shock Syndrome

Author(s) -

Shiranee Sriskandan,

Jon Cohen

Publication year - 2000

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/313827

Subject(s) - kinin , medicine , bradykinin , shock (circulatory) , kallikrein , toxic shock syndrome , immunology , staphylococcus aureus , chemistry , biology , biochemistry , bacteria , receptor , genetics , enzyme

A retrospective analysis of 7 patients with streptococcal toxic shock revealed isolated prolongation of the activated partial thromboplastin time, which returned to normal during recovery. Levels of factor XII were reduced in 2 patients who had single factor assays performed, consistent with activation of the kallikrein-kinin system. We speculate that bradykinin release following activation of the kallikrein-kinin system in streptococcal toxic shock may underlie the features of pain, capillary leaking, and severe hypotension characteristic of this syndrome.

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