Interferon- and Ribavirin Treatment of Hepatitis C in Children with Malignancy in Remission | Zendy

Bértil Christensson | Zendy; Thomas Wiebe | Zendy; A Akesson | Zendy; Anders Widell | Zendy

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Interferon- and Ribavirin Treatment of Hepatitis C in Children with Malignancy in Remission

Author(s) -

Bértil Christensson,

Thomas Wiebe,

A Akesson,

Anders Widell

Publication year - 2000

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/313709

Subject(s) - medicine , ribavirin , viremia , clearance , hepatitis c virus , gastroenterology , hepatitis c , interferon , malignancy , alpha interferon , interferon alfa , immunology , virus , urology

Twenty-eight cases of hepatitis C virus (HCV) infection were identified in children in a pediatric oncology ward during 2 nosocomial outbreaks. HCV infection spontaneously cleared in 6 patients (21%). Eleven patients with persistent HCV viremia who had malignant diseases in remission after treatment were given a 48-week course of combined therapy with interferon-alpha (5x106 U 3 times weekly) and oral ribavirin (15 mg/kg/d). Seven (64%) of the 11 patients had sustained virological responses 6 and 12 months after cessation of therapy. Side effects were common but generally were mild or moderate.

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