Acute Lung Injury in Leptospirosis: Clinical and Laboratory Features, Outcome, and Factors Associated with Mortality | Zendy

Paulo C. F. Marotto | Zendy; Cristiane MurtaNascimento | Zendy; José ElufNeto | Zendy; Marcia Schettini Marotto | Zendy; Lúcia Andrade | Zendy; Jaques Sztajnbok | Zendy; Antônio Carlos Seguro | Zendy

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Acute Lung Injury in Leptospirosis: Clinical and Laboratory Features, Outcome, and Factors Associated with Mortality

Author(s) -

Paulo C. F. Marotto,

Cristiane MurtaNascimento,

José ElufNeto,

Marcia Schettini Marotto,

Lúcia Andrade,

Jaques Sztajnbok,

Antônio Carlos Seguro

Publication year - 1999

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/313501

Subject(s) - medicine , leptospirosis , odds ratio , confidence interval , creatinine , acute kidney injury , prospective cohort study , multivariate analysis , gastroenterology , surgery , pathology

Forty-two consecutive patients with leptospirosis and acute lung injury who were mechanically ventilated were analyzed in a prospective cohort study. Nineteen patients (45%) survived, and 23 (55%) died. Multivariate analysis revealed that 3 variables were independently associated with mortality: hemodynamic disturbance (odds ratio [OR], 6.0; 95% confidence interval [CI], 0.9-38.8; P=. 047), serum creatinine level >265.2 micromol/L (OR, 10.6; 95% CI, 0. 9-123.7; P =.026), and serum potassium level >4.0 mmol/L (OR, 19.9; 95% CI, 1.2-342.8; P=.009). These observations can be used to identify factors associated with mortality early in the course of severe respiratory failure in leptospirosis.

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