A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels | Zendy

Zhuyuan Chen | Zendy; Sheng Lin | Zendy; Tianze Xie | Zendy; JinMing Lin | Zendy; Cecilia M. Canessa | Zendy

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A flexible GAS belt responds to pore mutations changing the ion selectivity of proton-gated channels

Author(s) -

Zhuyuan Chen,

Sheng Lin,

Tianze Xie,

JinMing Lin,

Cecilia M. Canessa

Publication year - 2021

Publication title -

the journal of general physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.064

H-Index - 127

eISSN - 1540-7748

pISSN - 0022-1295

DOI - 10.1085/jgp.202112978

Subject(s) - selectivity , biophysics , chemistry , depolarization , ion channel , ion , chemical physics , proton , membrane , membrane potential , ion transporter , biochemistry , physics , biology , receptor , organic chemistry , quantum mechanics , catalysis

Chen et al. computationally model the open conformation of the hASIC1a channel to predict that mutations that eliminate channel selectivity cause a widening of the GAS belt. Their findings implicate the GAS belt diameter in channel kinetics and ion selectivity.

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