Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function | Zendy

Laura-Marie Winterstein | Zendy; Kerri Kukovetz | Zendy; UlfPeter Hansen | Zendy; Indra Schroeder | Zendy; James L. Van Etten | Zendy; Anna Moroni | Zendy; Gerhard Thiel | Zendy; Oliver Rauh | Zendy

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Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function

Author(s) -

Laura-Marie Winterstein,

Kerri Kukovetz,

UlfPeter Hansen,

Indra Schroeder,

James L. Van Etten,

Anna Moroni,

Gerhard Thiel,

Oliver Rauh

Publication year - 2021

Publication title -

the journal of general physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.064

H-Index - 127

eISSN - 1540-7748

pISSN - 0022-1295

DOI - 10.1085/jgp.202012731

Subject(s) - gating , chemistry , biophysics , lipid bilayer , kcsa potassium channel , bilayer , conductance , ion channel , transmembrane protein , transmembrane domain , membrane , crystallography , biochemistry , biology , receptor , mathematics , combinatorics

Winterstein et al. use the natural diversity of small viral K + channels to address the impact of phospholipid bilayer composition on channel function. Single-channel recordings reveal a stimulating effect of anionic phospholipids on channel conductance and protein-specific effects on gating.

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