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REACTIONS OF RABBITS TO NON-HEMOLYTIC STREPTOCOCCI
Author(s) -
C. L. Derick,
C. H. Hitchcock,
Homer F. Swift
Publication year - 1930
Publication title -
the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.52.2.143s
Subject(s) - sign (mathematics) , streptococcus pyogenes , biology , mathematics , genetics , bacteria , mathematical analysis , staphylococcus aureus
The most satisfactory method thus far found for the induction and maintenance of a high degree of hypersensitiveness—"allergy," "hyperergy"—against non-hemolytic streptococci consists in the repeated production of small focal lesions with minimal doses of bacteria. After a preliminary sensitizing period of about 2 weeks' duration with either large initial, or small multiple daily inoculations, the later foci need be produced only at 7 to 10 day intervals. Chronicity of low-grade infection appears to be an important factor in the attainment of a high degree of hypersensitiveness.

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