Open AccessCrossing barriers in transplantation
Author(s) -
Hema Bashyam
Publication year - 2007
Publication title -
the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.2043fta
Subject(s) - transplantation , immunology , graft versus host disease , leukemia , histocompatibility , major histocompatibility complex , antigen , biology , medicine , human leukocyte antigen
In 1978, Jonathan Sprent and Robert Korngold proved that graft-versus-host disease (GVHD) is caused by donor T cells that attack the host's non-MHC antigens. T cell depletion of donor grafts has since become a staple of transplantation strategies to combat leukemia and other inherited blood disorders.
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