Open AccessIFNγ: Issuing macrophages a license to kill
Author(s) -
Hema Bashyam
Publication year - 2007
Publication title -
the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.2041fta
Subject(s) - intracellular , nitric oxide , cytokine , reactive oxygen species , macrophage , microbiology and biotechnology , enzyme , biology , chemistry , immunology , biochemistry , in vitro , endocrinology
T cells tell macrophages when to start making the toxic soup of lysosomal enzymes, reactive oxygen species, and nitric oxide that destroys intracellular pathogens. In 1983, Carl Nathan proved that this start signal comes in the form of the secreted cytokine IFNγ.
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