Open AccessLewis Thomas and droopy rabbit ears
Author(s) -
Hema Bashyam
Publication year - 2007
Publication title -
the journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.483
H-Index - 448
eISSN - 1540-9538
pISSN - 0022-1007
DOI - 10.1084/jem.20412fta
Subject(s) - proteases , papain , rheumatoid arthritis , endogeny , biology , pathology , medicine , immunology , enzyme , endocrinology , biochemistry
In 1956, Lewis Thomas discovered that injecting rabbits with a plant protease called papain caused their ears to collapse. This experiment led to the identification of the endogenous proteases that cause the tissue destruction seen in diseases such as rheumatoid arthritis.
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