Conserved meningeal lymphatic drainage circuits in mice and humans | Zendy

Laurent Jacob | Zendy; José M. Brito | Zendy; Stéphanie Lenck | Zendy; Céline Corcy | Zendy; Farhat Benbelkacem | Zendy; Luiz Henrique Geraldo | Zendy; Yunling Xu | Zendy; Jean-Mickael Thomas | Zendy; Marie-Rénée El Kamouh | Zendy; Myriam Spajer | Zendy; MarieClaude Potier | Zendy; Stéphane Haı̈k | Zendy; Michel Kalamarides | Zendy; Bruno Stankoff | Zendy; Stéphane Lehéricy | Zendy; Anne Eichmann | Zendy; JeanLéon Thomas | Zendy

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Conserved meningeal lymphatic drainage circuits in mice and humans

Author(s) -

Laurent Jacob,

José M. Brito,

Stéphanie Lenck,

Céline Corcy,

Farhat Benbelkacem,

Luiz Henrique Geraldo,

Yunling Xu,

Jean-Mickael Thomas,

Marie-Rénée El Kamouh,

Myriam Spajer,

MarieClaude Potier,

Stéphane Haı̈k,

Michel Kalamarides,

Bruno Stankoff,

Stéphane Lehéricy,

Anne Eichmann,

JeanLéon Thomas

Publication year - 2022

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20220035

Subject(s) - lymphatic system , cerebrospinal fluid , medicine , dural venous sinuses , glymphatic system , dura mater , anatomy , dorsum , skull , magnetic resonance imaging , pathology , meninges , paranasal sinuses , pia mater , radiology , surgery , thrombosis

Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained unclear. Here, we used light-sheet fluorescence microscopy (LSFM) imaging of mouse whole-head preparations after OVA-A555 tracer injection into the cerebrospinal fluid (CSF) and performed real-time vessel-wall (VW) magnetic resonance imaging (VW-MRI) after systemic injection of gadobutrol in patients with neurological pathologies. We observed a conserved three-dimensional anatomy of MLVs in mice and humans that aligned with dural venous sinuses but not with nasal CSF outflow, and we discovered an extended anterior MLV network around the cavernous sinus, with exit routes through the foramina of emissary veins. VW-MRI may provide a diagnostic tool for patients with CSF drainage defects and neurological diseases.

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