A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice | Zendy

Tianyang Mao | Zendy; Benjamin Israelow | Zendy; Carolina Lucas | Zendy; Chantal B. F. Vogels | Zendy; Maria Luisa Gomez-Calvo | Zendy; Olga Fedorova | Zendy; Mallery I. Breban | Zendy; Bridget L. Menasché | Zendy; Huiping Dong | Zendy; Melissa Linehan | Zendy; Tara Alpert | Zendy; F. Brito Anderson | Zendy; Rebecca Earnest | Zendy; Joseph R. Fauver | Zendy; Chaney C. Kalinich | Zendy; Ketty Munyenyembe | Zendy; Isabel M. Ott | Zendy; Mary E. Petrone | Zendy; Jessica E. Rothman | Zendy; Anne E. Watkins | Zendy; Craig B. Wilen | Zendy; Marie L. Landry | Zendy; Nathan D. Grubaugh | Zendy; Anna Marie Pyle | Zendy; Akiko Iwasaki | Zendy

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A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

Author(s) -

Tianyang Mao,

Benjamin Israelow,

Carolina Lucas,

Chantal B. F. Vogels,

Maria Luisa Gomez-Calvo,

Olga Fedorova,

Mallery I. Breban,

Bridget L. Menasché,

Huiping Dong,

Melissa Linehan,

Tara Alpert,

F. Brito Anderson,

Rebecca Earnest,

Joseph R. Fauver,

Chaney C. Kalinich,

Ketty Munyenyembe,

Isabel M. Ott,

Mary E. Petrone,

Jessica E. Rothman,

Anne E. Watkins,

Craig B. Wilen,

Marie L. Landry,

Nathan D. Grubaugh,

Anna Marie Pyle,

Akiko Iwasaki

Publication year - 2021

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20211818

Subject(s) - context (archaeology) , immunology , immune system , interferon , immunity , innate immune system , disease , chronic infection , agonist , medicine , biology , virology , receptor , paleontology

A stem-loop RNA (SLR) RIG-I agonist is effective in preventing and treating acute SARS-CoV-2 infection in mice. A single injection of SLR can clear chronic SARS-CoV-2 in immunocompromised mice. SLR is effective against the ancestral virus as well as variants of concern.

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