Neural control of immune cell trafficking | Zendy

Scott N. Mueller | Zendy

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Neural control of immune cell trafficking

Author(s) -

Scott N. Mueller

Publication year - 2022

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20211604

Subject(s) - leukocyte trafficking , immune system , inflammation , biology , immunology , effector , immunity , motility , microbiology and biotechnology , neuroscience , chemokine

Leukocyte trafficking between blood and tissues is an essential function of the immune system that facilitates humoral and cellular immune responses. Within tissues, leukocytes perform surveillance and effector functions via cell motility and migration toward sites of tissue damage, infection, or inflammation. Neurotransmitters that are produced by the nervous system influence leukocyte trafficking around the body and the interstitial migration of immune cells in tissues. Neural regulation of leukocyte dynamics is influenced by circadian rhythms and altered by stress and disease. This review examines current knowledge of neuro–immune interactions that regulate leukocyte migration and consequences for protective immunity against infections and cancer.

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