Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection | Zendy

Nina Le Bert | Zendy; Hannah Clapham | Zendy; Anthony T. Tan | Zendy; Wan Ni Chia | Zendy; C Tham | Zendy; Jane Mingjie Lim | Zendy; Kamini Kunasegaran | Zendy; Linda Wei Lin Tan | Zendy; CharlesAntoine Dutertre | Zendy; Nivedita Shankar | Zendy; Joey Ming Er Lim | Zendy; Louisa Sun | Zendy; Marina Zahari | Zendy; Zaw Myo Tun | Zendy; Vishakha Kumar | Zendy; Beng Lee Lim | Zendy; Siew Hoon Lim | Zendy; Adeline Chia | Zendy; YeeJoo Tan | Zendy; Paul Anantharajah Tambyah | Zendy; Shirin Kalimuddin | Zendy; David Chien Lye | Zendy; Jenny G. Low | Zendy; LinFa Wang | Zendy; Wei Yee Wan | Zendy; Li Yang Hsu | Zendy; Antonio Bertoletti | Zendy; Clarence C. Tam | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection

Author(s) -

Nina Le Bert,

Hannah Clapham,

Anthony T. Tan,

Wan Ni Chia,

C Tham,

Jane Mingjie Lim,

Kamini Kunasegaran,

Linda Wei Lin Tan,

CharlesAntoine Dutertre,

Nivedita Shankar,

Joey Ming Er Lim,

Louisa Sun,

Marina Zahari,

Zaw Myo Tun,

Vishakha Kumar,

Beng Lee Lim,

Siew Hoon Lim,

Adeline Chia,

YeeJoo Tan,

Paul Anantharajah Tambyah,

Shirin Kalimuddin,

David Chien Lye,

Jenny G. Low,

LinFa Wang,

Wei Yee Wan,

Li Yang Hsu,

Antonio Bertoletti,

Clarence C. Tam

Publication year - 2021

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20202617

Subject(s) - asymptomatic , immunology , elispot , immune system , proinflammatory cytokine , seroconversion , cytokine , medicine , virus , secretion , subclinical infection , cellular immunity , virology , biology , inflammation , t cell

The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2–specific T cells in individuals who clear SARS-CoV-2 without symptoms could reveal nonpathological yet protective characteristics. We longitudinally studied SARS-CoV-2–specific T cells in a cohort of asymptomatic (n = 85) and symptomatic (n = 75) COVID-19 patients after seroconversion. We quantified T cells reactive to structural proteins (M, NP, and Spike) using ELISpot and cytokine secretion in whole blood. Frequencies of SARS-CoV-2–specific T cells were similar between asymptomatic and symptomatic individuals, but the former showed an increased IFN-γ and IL-2 production. This was associated with a proportional secretion of IL-10 and proinflammatory cytokines (IL-6, TNF-α, and IL-1β) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2–specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2–infected individuals are not characterized by weak antiviral immunity; on the contrary, they mount a highly functional virus-specific cellular immune response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research