Persistent cellular immunity to SARS-CoV-2 infection | Zendy

Gaëlle Breton | Zendy; Pilar Mendoza | Zendy; Thomas Hägglöf | Zendy; Thiago Y. Oliveira | Zendy; Dennis Schaefer-Babajew | Zendy; Christian Gaebler | Zendy; Martina Turroja | Zendy; Arlene Hurley | Zendy; Marina Caskey | Zendy; Michel C. Nussenzweig | Zendy

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Persistent cellular immunity to SARS-CoV-2 infection

Author(s) -

Gaëlle Breton,

Pilar Mendoza,

Thomas Hägglöf,

Thiago Y. Oliveira,

Dennis Schaefer-Babajew,

Christian Gaebler,

Martina Turroja,

Arlene Hurley,

Marina Caskey,

Michel C. Nussenzweig

Publication year - 2021

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20202515

Subject(s) - immunology , pandemic , immune system , biology , immunity , antigen , covid-19 , cd8 , immunological memory , virology , t cell , medicine , disease , pathology , infectious disease (medical specialty)

SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 mo after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen-specific memory that could contribute to rapid recall responses. Recovered individuals also show enduring alterations in relative overall numbers of CD4+ and CD8+ memory T cells, including expression of activation/exhaustion markers, and cell division.

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