The many faces of the anti-COVID immune response | Zendy

Santosha A. Vardhana | Zendy; Jedd D. Wolchok | Zendy

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The many faces of the anti-COVID immune response

Author(s) -

Santosha A. Vardhana,

Jedd D. Wolchok

Publication year - 2020

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20200678

Subject(s) - covid-19 , immune system , acquired immune system , coronavirus , outbreak , immunity , viral infection , innate immune system , virology , biology , immunology , medicine , virus , disease , infectious disease (medical specialty) , pathology

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.

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