The role of IL-22 in intestinal health and disease | Zendy

Mary E. Keir | Zendy; Tangsheng Yi | Zendy; Timothy T. Lu | Zendy; Nico Ghilardi | Zendy

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The role of IL-22 in intestinal health and disease

Author(s) -

Mary E. Keir,

Tangsheng Yi,

Timothy T. Lu,

Nico Ghilardi

Publication year - 2020

Publication title -

the journal of experimental medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.483

H-Index - 448

eISSN - 1540-9538

pISSN - 0022-1007

DOI - 10.1084/jem.20192195

Subject(s) - intestinal epithelium , immunology , homeostasis , barrier function , biology , disease , interleukin 22 , epithelium , inflammatory bowel disease , cytokine , regulator , mucus , interleukin , microbiology and biotechnology , medicine , pathology , gene , ecology , genetics , biochemistry

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.

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